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・ CFBK-FM
・ CFBN
・ CFBO-FM
・ CFBR-FM
・ CFBS
・ CFBS-FM
・ CFBT
・ CfBT Education Trust
・ CFBT-FM
・ CFBU-FM
・ CFBV
・ CFBW-FM
・ CFBX-FM
・ CFBY-FM
・ CFC
CFC domain
・ CFC Hertha 06
・ CfC Stanbic Holdings
・ CFC Worldwide Short Film Festival
・ CFCA (disambiguation)
・ CFCA-FM
・ CFCB
・ CFCD-FM
・ CFCF
・ CFCF (musician)
・ CFCF-DT
・ CFCH-FM
・ CFCJ-FM
・ CFCL
・ CFCL Australia


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CFC domain : ウィキペディア英語版
CFC domain

In molecular biology, the CFC domain (Cripto_Frl-1_Cryptic domain) is a protein domain found at the C-terminus of a number of proteins including Cripto (or teratocarcinoma-derived growth factor). It is structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2.〔 CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.〔
The CFC domain appears to play a crucial role in the tumourigenic activity of Cripto proteins, as it is through the CFC domain that Cripto interferes with the onco-suppressive activity of Activins, either by blocking the Activin receptor ALK4 or by antagonising proteins of the TGF-beta family.
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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